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KMID : 0032220130250040479
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Annals of Dermatology
2013 Volume.25 No. 4 p.479 ~ p.482
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Extensive Psoriasis Induced by Pegylated Interferon Alfa-2a and Ribavirin in the Treatment of Chronic Hepatitis C
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Kim Gun-Wook
Jwa Seung-Wook
Song Margaret
Kim Hoon-Soo
Kim Byung-Soo
Kim Moon-Bum
Ko Hyun-Chang
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Abstract
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A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened drama-tically during therapy. Because of the extensive skin erup-tions, he stopped therapy for chronic hepatitis C and sub-sequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate oint-ment. After this, the psoriasis improved in a slow but comprehensive manner. Our case suggests that physicians should keep in mind the possibility of psoriasis as a side effect of interferon treatment for chronic hepatitis C. (Ann Der-matol 25(4) 479∼482, 2013)
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KEYWORD
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Hepatitis C, Peginterferon alfa-2a, Psoriasis, Ribavirin
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